These compounds presented strong cytotoxic effects against the following cancer cell lines: gastric (NUGC-3), nasopharyngeal (HONE-1), breast (MCF-7) and lung (A549) [43]. The excessive ERS levels additionally prompted autophagic cell death [76]. J Nat Prod. The oil obtained by cold pressure from Cucurbita pepo seeds is rich in antioxidant and antimicrobial components. Molecules. Cucurbitacins as potential anticancer agents: new insights on molecular ... 2022;154:113555. University of Michigan Hospital. Independent Evolutionary Origin for Insect Deterrent Cucurbitacins in ... Furthermore, when compared with other integrins, the triterpenoid compound significantly suppressed ITGA6 and ITGB4 expression, commonly overexpressed in breast cancer, in a time-dependent way. Use of cucurbitacins for lung cancer research and therapy Cucurbitacin structures are characterized by the tetracyclic cucurbitane nucleus (triterpenes) with a variety of oxygen substitutions at different positions. Maarisit W, Yamazaki H, Kanno S-I, Tomizawa A, Lee J-S, Namikoshi M. Protein tyrosine phosphatase 1B inhibitory properties of seco-cucurbitane triterpenes obtained from fruiting bodies of Russula lepida. Therefore, cucurbitacins are a class of promising anticancer drugs to be used alone or be intergraded in current chemotherapies and radiotherapies to treat many types of cancers. The study included the published papers with full text that highlighted the mechanisms and anticancer signaling pathways of cucurbitacins resulting from preclinical pharmacological studies. Notably, the expressions of ERK1 and MEK1 were significantly downregulated when compared with non-treated cells [78]. Vella FM, Cautela D, Laratta B. Staphylococcus aureus colonisation in patients from a primary regional hospital. 2020;9:35. Probiotics: versatile bioactive components in promoting human health. Medicina-Lithuania. Biosensing chips for cancer diagnosis and treatment: a new wave towards clinical innovation. Oxid Med Cell Longev. J Struct Biol. Kaushik U, Aeri V, Mir SR. Cucurbitacins—an insight into medicinal leads from nature. Front Chem. Similarly, combining gemcitabine or docetaxel with cucurbitacin B increases apoptosis, inhibiting the proliferation of MDA-MB-231 breast cancer cells in vitro. Domino's Farms Petting Farm. PubMed Google Scholar. Iqbal MJ, Javed Z, Herrera-Bravo J, Sadia H, Anum F, Raza S, Tahir A, Shahwani MN, Sharifi-Rad J, Calina D, Cho WC. Zhang J, Song Y, Liang Y, Zou H, Zuo P, Yan M, Jing S, Li T, Wang Y, Li D, et al. Aribi A, Gery S, Lee DH, Thoennissen NH, Thoennissen GB, Alvarez R, Ho Q, Lee K, Doan NB, Chan KT. 2014;34:4797–806. Calina D, Rosu L, Rosu AF, Ianosi G, Ianosi S, Zlatian O, Mitrut R, Docea AO, Rogoveanu O, Mitrut P, et al. 2022 Oct 26;15(11):1325. doi: 10.3390/ph15111325. Zlatian OM, Comanescu MV, Rosu AF, Rosu L, Cruce M, Gaman AE, Calina CD, Sfredel V. Histochemical and immunohistochemical evidence of tumor heterogeneity in colorectal cancer. Additionally, cucurbitacins exert strong synergistic anticancer effects when combined with clinically used chemotherapeutic drugs. 1995;36:1763–6. Cucurbitacin D combined with doxorubicin significantly increased p-p53 levels and suppressed p-Akt, p-NF-κB, p-Stat3, and Bcl-2 levels more than doxorubicin or cucurbitacin D alone. An official website of the United States government. Sci Rep. 2019;9:1–11. Nutrition. Cucurbitacins are extremely bitter compounds mainly present in Cucurbitaceae, where Luffa belongs. Metabolite Profiling and Quantitation of Cucurbitacins in ... - Nature Herein, we first discovered the excellent cytotoxicity of CuB towards . The HER2 inhibition was higher in the cell lines where the ILK1/YB-1/Twist signalling axis, identified as a regulator of HER2 expression, was also inhibited. J Transl Med. This particular integrin plays a role in tumour formation and angiogenesis, and cucurbitacin B was able to inhibit angiogenesis in human microvascular endothelial cells, dose-dependently, in concentrations as low as 100 nM [69]. Cancer Cell Int. Previous studies on the anti-tumour mechanism of CuB have mostly focused on cell apoptosis, and research on the ferroptosis-inducing effect has rarely been reported. 2022;22:246. Phytother Res. Cucurbitacin B (CuB) is a widely available triterpenoid molecule that exhibits various biological activities. The therapeutic molecule additionally inhibited the metabolic activity of TPA-induced MMP-9, by inactivating the extracellular signal-regulated kinase (ERK) 1/2, p38, and the Akt signaling pathway [61]. For example, the well-known vegetable Cucumis sativus (cucumber) rich in cucurbitacins A, B, C, D, and E, has been reported to alleviate symptoms of indigestion and constipation, to help with skin problems and to promote hair growth [17]. Anticancer Res. Cucurbitacins - A Promising Target for Cancer Therapy - PMC Cucurbitacins accumulate in varied amounts in plant organs of different cucurbit species (Table 1).C. Oxid Med Cell Longev. 17. They and their derivatives have been found in many plant families (including Brassicaceae, Cucurbitaceae, Scrophulariaceae, Begoniaceae, Elaeocarpaceae, Datiscaceae, Desfontainiaceae, Polemoniaceae, Primulaceae, Rubiaceae, Sterculiaceae, Rosaceae, and Thymelaeaceae), in some mushrooms (including Russula and Hebeloma) and even in some marine mollusks. Cucurbitacins have also been isolated from a few genera of mushrooms, including Hebeloma vinosophyllum, Russula lepida, and Leucopaxillus gentianeus. Bitter bottle gourd (Lagenaria siceraria) toxicity - PubMed Cancer Lett. Olmedo D, Rodríguez N, Vásquez Y, Solis P, Lopez-Perez J, Feliciano AS, Gupta M. A new coumarin from the fruits of Coutarea hexandra. The antiproliferative activity of cucurbitacin E on the brain in the malignant glioma GBM8401 human cell line was evaluated. Cancer Prev Res (Phila). government site. Qu Y, Cong P, Lin C, Deng Y, Li-Ling J, Zhang M. Inhibition of paclitaxel resistance and apoptosis induction by cucurbitacin B in ovarian carcinoma cells. For pancreatic cancer, treatment with cucurbitacin D caused cell cycle arrest at the G2/M phase, apoptosis induction, and intracellular ROS production in the AsPC-1 and Capan-1 cell lines. Login . Chen C-H, Kuo TC-Y, Yang M-H, Chien T-Y, Chu M-J, Huang L-C, Chen C-Y, Lo H-F, Jeng S-T, Chen L-FO. CAS 2004;67:1823–8. [1]: 87–130, Several other cucurbitacins have been found in plants. 2022;22:206. 2022;2022:5886269. Another important limitation is the weak and variable absorption of cucurbitacins; as a result, new nano-formulations are needed to increase absorption, bioavailability and transport to the target in tumor cells [117, 118]. As for apoptosis induction, cucurbitacin I treatment was linked to an increase in the cleavage of caspases-3, -7, -8, -9. 2021;12:600139–600139. 2017;14:145–52. The antitumour potential of cucurbitacin I on colon cancer was the focal point of Kim and colleagues’ research published in 2014. A different study found that cucurbitacin B disrupts the cytoskeletal network of MDA-MB-231 cells, resulting in fast morphologic changes and irregular polymerization of the microtubule network. 2020;48:1475–89. Hossain R, Ray P, Sarkar C, Islam MS, Khan RA, Khalipha ABR, Islam MT, Cho WC, Martorell M, Sharifi-Rad J, et al. 2022;2022:2910411. Phylogenetic analysis showed that Bi is the ortholog of cucurbitadienol synthase gene CPQ in squash (Cucurbita pepo) [7], There are several substances that can be seen as deriving from cucurbita-5-ene skeleton by loss of one of the methyl groups (28 or 29) attached to carbon 4; often with the adjacent ring (ring A) becoming aromatic. Cucurbitacin B and I inhibits the proliferation of colon cancer cell lines. Tanase A, Colita A, Ianosi G, Neagoe D, Branisteanu DE, Calina D, Docea AO, Tsatsakis A, Ianosi SL. Hou X, Meehan EJ, Xie J, Huang M, Chen M, Chen L. Atomic resolution structure of cucurmosin, a novel type 1 ribosome-inactivating protein from the sarcocarp of Cucurbita moschata. Int J Pharmacogn Phytochem Res. Translational pharmacological studies are also necessary to establish the exact dose in humans and the best way of their administration. In vivo, the derivative repressed the growth and proliferation of a syngeneic transplanted CT-26 BALB/c mice tumour model, and as observed in vitro, an increase in the apoptosis-related proteins and a decrease in the expression of G2/M phase cell cycle-related proteins was detected [77]. Sharifi-Rad J, Dey A, Koirala N, Shaheen S, El Omari N, Salehi B, Goloshvili T, Cirone Silva NC, Bouyahya A, Vitalini S, et al. They are generally known as the bitter principles of the Cucurbitaceae. Similarly, for gastric cancer, cucurbitacin B reversed the multi-drug resistance of the SGC7901/DDP gastric cancer cells by downregulating the drug-resistant protein HIF-1a and P-pg. Die Pharmazie-Int J Pharm Sci. showed that treatment with low doses of cucurbitacin B and methotrexate synergistically inhibit the AKT and mTOR signaling pathways in human osteosarcoma cells both in vivo and in vitro improving the tumour suppression rate [93]. Cucurbitacin B, an oxygenated tetracyclic triterpenoid compound extracted from the Thai medicinal plant Trichosanthes cucumerina L., has been reported to have several biological activities including anti-inflammatory, antimicrobial and anticancer. The estimated incidence rate worldwide is 4 million per year, with a peak incidence at the age of 15–19 years [110]. 2022;11:321–9. 2022;14:190. 2020;78:110788. Ungureanu A, Zlatian O, Mitroi G, Drocas A, Tirca T, Calina D, Dehelean C, Docea AO, Izotov BN, Rakitskii VN, et al. Wang et al. Furthermore, they also demonstrated a protein tyrosine phosphatase 1B (PTP1B) inhibitory activity—a compound manipulated as a negative regulator in the signal transduction via insulin and leptin pathways—without showing cytotoxicity [51, 52]. This paper provides a summary of recent research progress on the anticancer property of cucurbitacins and the various intracellular signaling pathways involved in the regulation of cancer cell proliferation, death, invasion, and migration. Interestingly, this family used to be known as Cruciferae owing to their cruciform appearance and flower shape [37]. Front Pharmacol. The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer. Ann Arbor doesn't have a zoo, but if you're looking for fun, fuzzy activities that will delight the young animal lovers in your life, consider making a trip to Domino's Farms Petting Farm. Oxid Med Cell Longev. They concluded that the Cucumis melo by-products are a source of polyphenols and tannins, responsible for antioxidant and anticarcinogenic properties, respectively. Pharmacological properties of bergapten: mechanistic and therapeutic aspects. Artemisia spp. The different cucurbitacins have been studied in experimental preclinical pharmacological studies and found to possess anticancer properties for a myriad of cancer types (Table 2). Natural compounds or their derivatives against breast cancer: a computational study. The Role of Natural Products as Inhibitors of JAK/STAT Signaling Pathways in Glioblastoma Treatment.
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